Wednesday, October 30, 2013

MMWR Vaccine coverage among 2012-2013 kindergartners

Chapter 8



       School vaccination assessments are used to provide information for the state and local institutions about who in their community has vaccine coverage or vaccine exemption. This assessment can provide explanations when looking at where there is a clustering of vaccine preventable diseases. It allows state/local institutions to develop campaigning strategies on where and how to target a particular group where we see a clustering of vaccine preventable infections.

      An assessment like this was done on kindergartners entering the public school system year 2012-2013 in all 50 states by the CDC. The data was reported in the Morbidity and Mortality Weekly Report August 2, 2013.

      While reviewing the data I came upon some very interesting facts. Over all as a nation we did very well with vaccination coverage this academic year, it was reported that vaccine coverage was about 95%, which is the national target coverage rate recommended by HEALTHY PEOPLE 20/20. The HEALTHY PEOPLE 20/20 recommend that the nation keep a 95% coverage level for "2 doses of MMR vaccine, 4 doses of DTaP† vaccine, and 2 doses of varicella vaccine"( MMWR 62(30);607-612). Nevertheless, the rest of the 5% of people that were not covered could pose a problem. We see that high vaccine exemption rates and low vaccination could cluster in communities and that could lead to the introduction of a vaccine preventable disease that could cause an outbreak and potentially harm a lot of people. 

     The data reported that among all 50 states and D.C vaccine exemption were allowed. Specifically 46/50 of the states allowed religious exemptions, 18/50 allowed philosophic exemptions and 2/50 (Mississippi and West Virginia) did not allow either religious or philosophic exemptions but they did allow other exemptions. Regardless of all of these exemptions, 48 states and D.C reported a 94.5% median coverage of the mandatory 2 dose MMR vaccine. This percentage ranged from (85.7% coverage in Colorado to 99.9% coverage in Mississippi). The median percentage for DTap vaccine was 95.1% ranging from (82.9% in Colorado to 99.9% in Mississippi). And lastly the median percentage for the 2 dose varicella was 93.8% ranging from (84.6% in Colorado to 99.9% in Mississippi). It is important to note that 91,453 out of 4,242,558 kindergarteners surveyed reported exemptions. This is valuable information when trying develop "health communication strategies to help parents understand the risks for vaccine-preventable diseases and the benefits of vaccinations to the health of their children and other 
kindergarteners"(MMWR 62(30);607-612). 

     What this survey provided state/local programs with, was information on where a VPD outbreak could happen. The data reported in this article did have some data collecting set backs. For example, there were three different methods used to collect information. Those were a public census, a IIs immunization information systems, voluntary resopnse or  combination of the three. There were no data for home schooled children. There was also another discrepancy with the data collection only 12/50 states were concordant with the CDC requirements for data collection and that at the time of collection some children were in the process of filling out their vaccine schedules and once they were compliant with the vaccine schedule this information was not updated in the data. 

     If you would like to take a look at the report and analyze the data for carefully click here. You will find the full report and data. This picture below is just a representation of the states that had more than one vaccine exemption for kindergartner in the academic year 2012-2013. 



First Image: http://www.ubm1.org/vaccines.jpg

Article reference : "Vaccination Coverage Among Children in Kindergarten — United States, 2012–13 School Year." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 02 Aug. 2013. Web. 30 Oct. 2013. <http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6230a3.htm>.

Tuesday, October 22, 2013

Using cat virus as a model for an HIV vaccine!





In this weeks blog we will be critiquing a virology paper on the development of an HIV vaccine using a cat virus as a model. The name of the paper is called Feline Immunodeficiency Virus Model for Designing HIV/AIDS Vaccines. You can click on this link if you would like to access the paper. 

Let me just start by saying this was a very interesting article and it definitely got me thinking about vaccine design. The paper focused on a feline virus called FIV(feline acquired immunodeficiency) that is a distant cousin of HIV and let me just make the distinction before we continue, the scientist claim that this FIV in cats is the equivalent of HIV in humans. The authors of this paper are researchers at UF and UCSF.


The researchers proposed that we use the FIV as a model to develop an HIV vaccine. The reason why this would be beneficial is because apparently the FIV is able to make a protein that has anti-HIV properties. They saw that when they incubated HIV infected T cells with FIV, "one particular peptide region on FIV triggered patients' T cells to kill HIV"(Yamamoto). The scientists in this paper think that they can develop a vaccine that targets human T cells, which is something that has never been done before. The researchers think they can design a T cell HIV vaccine that is able to activate a human's immune response against the FIV or AIDS. 


Reading this paper I was very excited because it proposed a new way to target the immune system. There were many reasons why this would be very hard to do. But the paper does propose many new ways in which we would be able to use FIV as a model for an HIV vaccine. 



Paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721975/#!po=55.6818

Tuesday, October 15, 2013

Some Frequently asked question about vaccines

Chapter 6


FAQS about vaccines

  1. Are there any vaccine side effects? And if there are side effects are they severe? There are side effects with vaccines, but they are usually mild and non life threatening.
  2. Why should I vaccinate my child? Why is it important? Its is important to vaccinate your child so he/she has protection from deadly diseases. It is important every child is vaccinated because that would prevent the spread of disease among children and other populations.
  3. Does the MMR vaccine really cause autism? No the MMR vaccine does not cause austism. There are no links between autism and the MMR vaccine. The article that suggested this has been disproven.
  4. What disease do the vaccine prevent? Vaccines prevent a lot of diseases both bacterial and viral. Here is a link where you will find vaccine preventable diseases. http://www.cdc.gov/vaccines/vpd-vac/default.htm
  5. Where can I get vaccines? You can get a vaccine at pharmacies, doctors offices, public clinics, and any other departments that offer health care services. 
  6. How much do vaccine cost? Vaccines are usually covered by insurance and if you are not insured here is a link with detailed prices of vaccines. http://www.cdc.gov/vaccines/programs/vfc/awardees/vaccine-management/price-list/
  7. What kind of materials are in vaccines? And do they hurt my body? Vaccines contain animal products, they sometimes contain yeast and other food products that could be harmful to people who have an allergic reaction to vaccines.
  8. Do vaccine only apply to children? No they do not there are some vaccines that can be administered to adults and adults can also get booster shots. 
  9. I am an uninsured illegal immigrant how can I get vaccinated? You can go to a doctors office and pay for your vaccine. Although some states offer free vaccines for undocumented workers. And definitely free vaccines should be offered to your child.
  10. How are vaccines made? Are they really made in eggs? Some vaccines are made in eggs this picture below is how they make flu vaccines. 
















Wednesday, October 9, 2013

What you should know about the flu this year.



So it's flu season and everyone is rushing to their clinics or pharmacies for the flu shot. It seems the flu has a way of always showing up around the fall and winter months. But what should you expect this flu season? Today we will talk about how to prepare for flu season, where to get the flu vaccine, and learn how many vaccines are available this year. Which is information that everyone has access to on the CDC website.

How to Prepare for Flu season 2013-2014

So flu season typically starts in January and February but flu activity usually starts around October. And because "epidemics of the flu happen every year, the timing, length and severity varies" (CDC). Therefore in order to prepare for the flu season the CDC recommends that anyone over the age of 6 months get a yearly flu vaccine. This is the most important step in protecting yourself from the flu. Even though the flu does change very often, the vaccine protects against the three main flu strains. In addition to the flu vaccine, "STAY AWAY" from sick people.



Where to get a flu vaccine

You can get a flu vaccine at your doctors office, pharmacy, public clinic, college health facility, and sometime they are even provided by your employer. And get the vaccine soon because manufacturers only project that about 135 million doses of flu vaccines will be available this 2013-2014 year which mean that about 200 million Americans will not get a chance to get the flu shot.

What kind of vaccine are available?



Like I had mentioned above most flu vaccines protect against three strains and that is why it is called "trivalent". But there are flu vaccines that are "quadrivalent". The differences in these vaccine has to do with the types of strains that it protects against and the how the vaccine was developed. The CDC does not recommend one vaccine over the other. Also most trivalent vaccines are in a injection form where as the quadrivalent comes in a nasal spray. Here is a link of the recommended flu vaccines, it shows how they were manufactured and what type of vaccine is recommended for you: http://www.cdc.gov/flu/protect/vaccine/quadrivalent.htm

In conclusion you should really plan on getting the flu vaccine this year, it gives you yearly protection against the flu and get it soon because once flu season really starts to get into gear, there might not be anymore shots left. Also if you want to you can click on this hyperlink that will take to the CDC website that will tell you everything you need to know about the influenza vaccine and its effectiveness.
http://www.cdc.gov/flu/about/season/flu-season-2013-2014.htm




First image: http://www.empowernetwork.com/donandnatalie/files/2013/01/Flu-1.jpg

Second Image: http://wakemedvoices.org/wp-content/uploads/2012/12/blowing-nose.jpg

Third image: http://www.funi-pics.com/album/I-hate-flu-season.jpg